| 翻訳と辞書 |
| Genes to Cognition Project ： ウィキペディア英語版 |
Genes to Cognition Project
Genes to Cognition (G2C) is a neuroscience research programme that studies genes, the brain and behaviour in an integrated manner. It is engaged in a large-scale investigation of the function of molecules found at the synapse. This is mainly focused on proteins that interact with the NMDA receptor, a receptor for the neurotransmitter, glutamate, which is required for processes of synaptic plasticity such as long-term potentiation (LTP). One key discovery that led to the G2C project was the characterization of a group of proteins that interact with this receptor, called the "NMDA Receptor Complex (NRC)" and the observation that dysfunctions of many of these proteins are characteristic of numerous diseases of the nervous system.〔Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. Nature Neuroscience 3, 661-669 (2000) () 〕 The NRC contains 185 proteins, 48 of which have so far been implicated in 54 human nervous system disorders.〔Synapse proteomics of multiprotein complexes: en route from genes to nervous system diseases. Human Molecular Genetics 14, R225-R234. () 〕 The molecular evolution of the NRC is also an active area of research, and it has been shown that an increase in the complexity of these signaling proteins at synapses has evolved alongside the enhanced cognitive capacities of humans and other higher vertebrates.〔Evolutionary expansion and anatomical specialization of synapse proteome complexity. Nature Neuroscience 11, 799 - 806 (2008) () 〕
==Scientific Strategy==
The activities of the Genes to Cognition Project encompass a wide range of scientific specialisms, reflecting the diversity of information that must be integrated to advance understanding of the brain. Following from ( synapse proteomics ) experiments to identify candidate proteins for further investigation, G2C has undertaken to knock out many of these by gene targeting in mice and has established a number of high-throughput platforms for evaluating the effect of these genetic manipulations on brain function.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
■ウィキペディアで「Genes to Cognition Project」の詳細全文を読む
スポンサード リンク
| 翻訳と辞書 : 翻訳のためのインターネットリソース |
Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.
|
|